Inhibition of astroglial hemichannels ameliorates infrasonic noise induced short-term learning and memory impairment.

ABSTRACT: As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research has shown that infrasound impairs cognitive function, especially the ability for learning and memory. Previously, we demonstrated that impaired learning and memory induced by infrasound was closely related with glia activation; however, the underlying mechanisms remain unclear. Connexin 43 hemichannels (Cx43 HCs), which are mainly expressed in hippocampal astrocytes, are activated under pathological conditions, lending support to the hypothesis that Cx43 HCs might function in the impaired learning and memory induced by infrasound. This study revealed that that blocking hippocampal Cx43 HCs or downregulating hippocampal Cx43 expression significantly alleviated impaired learning

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10726613 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature