Acute and continuous exposure of airborne fine particulate matter (PM_2.5): diverse outer blood-retinal barrier damages and disease susceptibilities.

ABSTRACT:

Background

The association between air pollution and retinal diseases such as age-related macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is unknown. Damage to the outer blood-retinal barrier (oBRB), which consists of the retinal pigment epithelium (RPE) and choriocapillaris, is crucial in the development of fundus diseases.

Objectives

To describe the effects of airborne fine particulate matter (PM_2.5) on the oBRB and disease susceptibilities.

Methods

A PM_2.5-exposed mice model was established through the administration of eye drops containing PM_2.5. Optical coherence tomography angiography, transmission electron microscope, RPE immunofluorescence staining and Western blotting were applied to study the

SUBMITTER: Gu Y 

PROVIDER: S-EPMC10726629 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature