The Inflammation Biomarker GlycA Reflects Plasma N-Glycan Branching.

ABSTRACT:

Background

GlycA is a nuclear magnetic resonance (NMR) signal in plasma that correlates with inflammation and cardiovascular outcomes in large data sets. The signal is thought to originate from N-acetylglucosamine (GlcNAc) residues of branched plasma N-glycans, though direct experimental evidence is limited. Trace element concentrations affect plasma glycosylation patterns and may thereby also influence GlycA.

Methods

NMR GlycA signal was measured in plasma samples from 87 individuals and correlated with MALDI-MS N-glycomics and trace element analysis. We further evaluated the genetic association with GlycA at rs13107325, a single nucleotide polymorphism resulting in a missense variant within SLC39A8, a manganese transporter that influences N-glycan branching, both in our sa

SUBMITTER: Noel M 

PROVIDER: S-EPMC10726709 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature