The impact of epilepsy and antiseizure medications on pregnancy and neonatal outcomes: A nationwide cohort study.

ABSTRACT:

Purpose

Our objective was to assess the adverse outcomes during pregnancy, as well as for the fetus and neonates, in women with epilepsy, both with and without the use of antiseizure medications (ASMs).

Methods

A cohort of singleton pregnancies between January 1, 2004 and December 31, 2014 was identified using the Taiwan National Health Database. The pregnancies were categorized into ASM exposure, ASM nonexposure, and control (consisting of women without an epilepsy diagnosis) groups. We recorded adverse outcomes in neonates and documented pregnancy complications. The generalized estimating equation with logit link was used to estimate adjusted odds ratios.

Results

There were 629 singleton pregnancies in the group exposed to ASMs, 771 in the epilepsy group without ASM

SUBMITTER: Kuo CY 

PROVIDER: S-EPMC10726760 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature