Proteomic and metabolomic characterizations of moyamoya disease patient sera.

ABSTRACT:

Background

The pathogenesis of moyamoya disease (MMD) is unclear. Inflammation and immune imbalance have been identified as potential factors contributing to the occurrence and progression of MMD. However, the specific proteins and metabolites responsible for triggering this process are yet to be established. The purpose of this study is to identify differentially expressed proteins and metabolites in patients with MMD and perform Kyoto Encyclopedia of Genes and Genomes pathway integration analysis to pinpoint crucial proteins and metabolites involved in the disease.

Methods

We performed untargeted metabolomic and data-independent acquisition proteomic analyses on the serum samples of individuals with MMD and healthy controls (HC).

Results

In patients with MMD versus

SUBMITTER: Guo Q 

PROVIDER: S-EPMC10726768 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature