Effects of different types of neonatal pain on somatosensory and cognitive development in male juvenile rats.

ABSTRACT:

Background

Premature infants are inevitably exposed to painful events, including repetitive procedures, inflammation, or mixed stimulation that may induce long-term behavioral outcomes. Here, we set up three neonatal painful models to investigate their long-term effect on somatosensation and cognition.

Methods

Three types of neonatal pain models in rat were set up. Rat pups were randomly assigned to four groups. The needling pain (NP) group received repetitive needle pricks on the paws from the day of birth (PD0) to postnatal day 7 (PD7) to mimic the diagnostic and therapeutic procedures. The inflammatory pain (IP) group received the injection of carrageenan into the left hindpaw at PD3 to induce IP in peripheral tissues. The mixed pain group received a combination of the NP

SUBMITTER: Ling R 

PROVIDER: S-EPMC10726798 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature