Association of white matter hyperintensities with long-term EGFR-TKI treatment and prediction of progression risk.

ABSTRACT:

Purpose

The purpose of this study was to test the hypothesis that brain white matter hyperintensities (WMH) are more common in patients receiving epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and identify clinical risk factors associated with WMH.

Experimental design

This multiple-center, prospective cohort study was conducted from March 2017 to July 2020. Two groups of patients with non-small cell lung cancer (NSCLC) who received or did not receive EGFR-TKI were included and followed up for more than 24 months. The progression of WMH was defined as an increase of ≥1 point on the Fazekas visual rating scale between the baseline and at the 2-year follow-up. A modified Poisson regression model was performed to evaluate risk factors on increased WMH load

SUBMITTER: Yang H 

PROVIDER: S-EPMC10726800 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature