The causal effects between selenium levels and the brain cortical structure: A two-sample Mendelian randomization study.

ABSTRACT: Extensive research has demonstrated the critical role of selenium (Se) and selenoproteins in brain function and cognition. However, the impact of Se on brain cortical structure remains enigmatic. Therefore, this study used Mendelian randomization (MR) analysis to investigate the causal effect between Se levels and brain cortical structure.

Methods

This study utilizes 11 genetic variants associated with Se level variations, extracted from a large-scale genome-wide association study (GWAS) encompassed circulating Se levels (n = 5477) and toenail Se levels (n = 4162) in the European population. Outcome data were sourced from the summary statistics of the ENIGMA Consortium, comprising GWAS data from 51,666 individuals. The variables include cortical surface area (SA), thickness (TH) at

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10726828 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature