Circadian clock crosstalks with autism.

ABSTRACT:

Background

The mechanism underlying autism spectrum disorder (ASD) remains incompletely understood, but researchers have identified over a thousand genes involved in complex interactions within the brain, nervous, and immune systems, particularly during the mechanism of brain development. Various contributory environmental effects including circadian rhythm have also been studied in ASD. Thus, capturing the global picture of the ASD-clock network in combined form is critical.

Methods

We reconstructed the protein-protein interaction network of ASD and circadian rhythm to understand the connection between autism and the circadian clock. A graph theoretical study is undertaken to evaluate whether the network attributes are biologically realistic. The gene ontology enrichment an

SUBMITTER: Yurdakul E 

PROVIDER: S-EPMC10726833 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature