Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease.

ABSTRACT:

Introduction

Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in Alzheimer's disease (AD). Both have an important relation to cognition and potential therapeutic implications. We aimed to study a possible relationship between SEA and sleep disturbances in AD.

Methods

In this cross-sectional study, we performed a 24-h ambulatory EEG and polysomnography in 48 AD patients without diagnosis of epilepsy and 34 control subjects.

Results

SEA, mainly detected in frontotemporal brain regions during N2 with a median of three spikes/night [IQR1-17], was three times more prevalent in AD. AD patients had lower sleep efficacy, longer wake after sleep onset, more awakenings, more N1%, less REM sleep and a higher apnea-hypopnea index (AHI) and oxygen desatu

SUBMITTER: Devulder A 

PROVIDER: S-EPMC10726840 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature