AARS2 as a novel biomarker for prognosis and its molecular characterization in pan-cancer.

ABSTRACT:

Introduction

The mitochondrial alanyl-tRNA synthetase 2 (AARS2) as one of aminoacyl-tRNA synthases (ARSs) performs amino acid transportation and involves protein synthesis. However, its role in cancer remains largely unexplored.

Methods

In this study, more than 10,000 samples were enrolled to explore genomic alterations, biological function, prognosis, and clinical treatment based on AARS2 across pan-cancer. The molecular characterization of AARS2 was confirmed in hepatocellular carcinoma (HCC) using proteomics analysis, quantitative real-time PCR, western blotting, immunohistochemical staining, and cell experiments.

Results

For genomic landscape, the AARS2 was dramatically upregulated in multiple cancers, which might be mainly caused by copy number alteration rather

SUBMITTER: Liu L 

PROVIDER: S-EPMC10726843 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature