White matter microstructure is differently associated with executive functioning in youth born with congenital heart disease and youth born preterm.

ABSTRACT:

Introduction

Executive function deficits and adverse psychological outcomes are common in youth with congenital heart disease (CHD) or born preterm. Association white matter bundles play a critical role in higher order cognitive and emotional functions and alterations to their microstructural organization may result in adverse neuropsychological functioning. This study aimed to examine the relationship of myelination and axon density and orientation alterations within association bundles with executive functioning, psychosocial well-being, and resilience in youth with CHD or born preterm.

Methods

Youth aged 16 to 26 years born with complex CHD or preterm at ≤33 weeks of gestational age and healthy controls completed a brain MRI and self-report assessments of executive functi

SUBMITTER: Easson K 

PROVIDER: S-EPMC10726855 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature