The mitotic cell cycle-associated nomogram predicts overall survival in lung adenocarcinoma.

ABSTRACT:

Background

This study aimed to develop a prognostic model for lung adenocarcinoma (LUAD) associated with mitotic cell cycle. The model will predict the probability of survival at different time points and serve as a reference tool to evaluate the effectiveness of LUAD treatment.

Methods

A cohort of 442 patients with LUAD from the gene expression omnibus (GEO) database was randomly divided into a training group (n = 299) and a validation group (n = 99). The least absolute shrinkage and selection operator (LASSO)-COX algorithm was used to reduce the number of predictors based on the clinicopathological and RNA sequencing data to establish mutant characteristics that could predict patient survival. Additionally, gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG)

SUBMITTER: He X 

PROVIDER: S-EPMC10726878 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature