Genome-Wide Assessment of Shared Genetic Architecture Between Rheumatoid Arthritis and Cardiovascular Diseases.

ABSTRACT:

Background

Patients with rheumatoid arthritis (RA) have a 2- to 10-fold increased risk of cardiovascular disease (CVD), but the biological mechanisms and existence of causality underlying such associations remain to be investigated. We aimed to investigate the genetic associations and underlying mechanisms between RA and CVD by leveraging large-scale genomic data and genetic cross-trait analytic approaches.

Methods and results

Within UK Biobank data, we examined the genetic correlation, shared genetics, and potential causality between RA (N_cases=6754, N_controls=452 384) and cardiovascular diseases (CVD, N_cases=44 238, N_controls=414 900) using linkage disequilibrium score regression, cross-trait meta-analysis, and Mendelian randomiz

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10727280 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature