Association of Depression and Adherence to Oral Anticoagulation in Patients With Atrial Fibrillation.

ABSTRACT:

Background

Adherence to oral anticoagulation is essential for stroke prevention in atrial fibrillation (AF). Depression has been associated with decreased adherence to medications in multiple disease states and in AF is further associated with increased risk of stroke. We hypothesized that individuals with depression and AF have decreased adherence to anticoagulation than those without depression.

Methods and results

We used administrative claims data to identify individuals with AF initiating anticoagulation with direct-acting oral anticoagulants (DOACs) or warfarin between 2013 and 2019. We quantified adherence using proportion of days covered, categorized as limited (proportion of days covered, <80%), adequate (proportion of days covered, ≥80% to <90%), or optimal (propor

SUBMITTER: Lapa ME 

PROVIDER: S-EPMC10727299 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature