Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background

Patients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile acid-activated receptors exploited in the treatment of nonalcoholic fatty liver disease: whether dual GPBAR1/FXR agonists synergize with statins in the treatment of the liver and cardiovascular components of nonalcoholic fatty liver disease is unknown.

Methods and results

Investigations of human aortic samples obtained from patients who underwent surgery for aortic aneurysms and Gpbar1^-/-, Fxr^-/-, and dual Gpbar1^-/-Fxr^-/- mice demonstrated that GPBAR1 and FXR are expressed in the aortic wall and regulate endothelial cell/macrophage interactions. The

SUBMITTER: Marchiano S 

PROVIDER: S-EPMC10727350 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature