Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study.

ABSTRACT:

Background

The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia.

Methods and results

Data were obtained from the UK Biobank. Information on the diagnosis of CHD and dementia was collected at baseline and follow-ups. Propensity score matching method and Cox proportional hazards models were used to evaluate the association between different ages at CHD onset and incident dementia. A total of 432 667 adults (mean±SD age, 56.9±8.1 years) were included, of whom 11.7% had CHD. Compared with participants without CHD, participants with CHD exhibited higher risks of developing all-cause dementia, Alzheimer's disease, and

SUBMITTER: Liang J 

PROVIDER: S-EPMC10727352 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature