Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications.

ABSTRACT: Modern humans carry both Neanderthal and Denisovan (archaic) genome elements that are part of the human gene pool and affect the life and health of living individuals. The impact of archaic DNA may be particularly evident in pharmacogenes-genes responsible for the processing of exogenous substances such as food, pollutants, and medications-as these can relate to changing environmental effects, and beneficial variants may have been retained as modern humans encountered new environments. However, the health implications and contribution of archaic ancestry in pharmacogenes of modern humans remain understudied. Here, we explore 11 key cytochrome P450 genes (CYP450) involved in 75% of all drug metabolizing reactions in three Neanderthal and one Denisovan individuals and examine archaic introgr

SUBMITTER: Wroblewski TH 

PROVIDER: S-EPMC10727477 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature