Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.

ABSTRACT: The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cells migrating from the neural crest and remains largely unchanged thereafter. Here, we show that the lineage composition of maturing ENS changes with time, with a decline in the canonical lineage of neural-crest derived neurons and their replacement by a newly identified lineage of mesoderm-derived neurons. Single cell transcriptomics and immunochemical approaches establish a distinct expression profile of mesoderm-derived neurons. The dynamic balance between the proportions of neurons from these two different lineages in the post-natal gut is dependent on

SUBMITTER: Kulkarni S 

PROVIDER: S-EPMC10727506 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature