Hepatocellular Carcinoma Subtyping and Prognostic Model Construction Based on Chemokine-Related Genes.

ABSTRACT:

Background

Chemokines not only regulate immune cells but also play significant roles in development and treatment of tumors and patient prognoses. However, these effects have not been fully explained in hepatocellular carcinoma (HCC).

Materials and methods

We conducted a clustering analysis of chemokine-related genes. We then examined the differences in survival rates and analyzed immune levels using single-sample Gene Set Enrichment Analysis (ssGSEA) for each subtype. Based on chemokine-related genes of different subtypes, we built a prognostic model in The Cancer Genome Atlas (TCGA) dataset using the survival package and glmnet package and validated it in the Gene Expression Omnibus (GEO) dataset. We used univariate and multivariate regression analyses to select independen

SUBMITTER: Guo Q 

PROVIDER: S-EPMC10727522 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature