Trabecular Bone Score Improves Early After Successful Kidney Transplantation Irrespective of Antiresorptive Therapy and Changes in Bone Mineral Density.

ABSTRACT:

Background

Trabecular bone score (TBS) is a new tool to assess trabecular bone microarchitecture based on standard dual-energy x-ray absorptiometry (DXA) of lumbar spine images. TBS may be important to assess bone quality and fracture susceptibility in kidney transplant recipients (KTRs). This study aimed to investigate the effect of different bone therapies on TBS in KTRs.

Methods

We reanalyzed DXA scans to assess TBS in 121 de novo KTRs at baseline, 10 wk, and 1 y. This cohort, between 2007 and 2009, participated in a randomized, placebo-controlled trial evaluating the effect of ibandronate versus placebo in addition to vitamin D and calcium.

Results

Although bone mineral density (BMD) Z scores showed a subtle decrease in the first weeks, TBS Z scores increased from

SUBMITTER: Strommen RC 

PROVIDER: S-EPMC10727526 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature