Intrahepatic neutrophil accumulation and extracellular trap formation are associated with posthepatectomy liver failure.

ABSTRACT:

Background

Posthepatectomy liver failure (PHLF) represents a life-threatening complication with limited therapeutic options. Neutrophils play a critical and dynamic role during regeneratory processes, but their role in human liver regeneration is incompletely understood, especially as underlying liver disease, detectable in the majority of patients, critically affects hepatic regeneration. Here we explored intrahepatic neutrophil accumulation and neutrophil extracellular traps (NETs) in patients with PHLF and validated the functional relevance of NETs in a murine partial hepatectomy (PHx) model.

Methods

We investigated the influx of neutrophils, macrophages, eosinophils, and mast cells and the presence of their respective extracellular traps in liver biopsies of 35 patients

SUBMITTER: Brunnthaler L 

PROVIDER: S-EPMC10727591 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature