Association between allergic rhinitis and hypertension risk: A bidirectional 2-sample mendelian randomization study.

ABSTRACT: Previous studies have suggested a potential association between allergic rhinitis (AR) and hypertension, but the genetic basis remains unclear. In this study, we aimed to explore the genetic correlation and potential causal association between AR and hypertension. Using a large-scale genome-wide association study (GWAS) public database, we conducted meticulous screening to acquire the most up-to-date GWAS data on single nucleotide polymorphisms (SNPs) relevant to AR and hypertension, with a significance threshold of P < 5 × 10-8. Then, we investigated the causal association between AR and hypertension through mendelian randomization (MR) analysis. We also performed reverse MR analysis to assess the possibility of reverse causality. Sensitivity analyses encompassed various factors, includin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10727617 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature