Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation.

ABSTRACT:

Background

Natural killer (NK) cells are enriched in the liver and are the main regulators in liver transplantation regarding rejection or tolerance, viral infection, or tumor recurrence. Immunosuppression consists of a triple drug standard regimen comprising tacrolimus (TAC) and corticosteroids (CS) with either mycophenolate mofetil (MMF) or sirolimus (SIR)/everolimus (EVE). The aim of this study was to evaluate the impact of trough levels of these regimens under clinical conditions and exposure on human NK-cell activity and function in order to better understand the antiviral and anti-tumor effects of mammalian target of rapamycin inhibitor (mTORI).

Methods

Peripheral blood mononuclear cells (PBMCs) were collected from liver transplant recipients and healthy controls. Numb

SUBMITTER: Qin R 

PROVIDER: S-EPMC10727815 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature