Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through Mendelian randomization.

ABSTRACT: Despite numerous observational studies indicating an increased risk of cutaneous melanoma (CM) due to childhood sunburn, no studies have established a definitive cause-and-effect relationship. Therefore, our objective was to employ a Mendelian randomization (MR) design to explore a possible causal association between childhood sunburn and the risk of CM. To investigate the causal relationship between childhood sunburn and CM, we used large-scale genetic summary-level data from genome-wide association studies (GWAS), including childhood sunburn (n = 346,955) and CM (n = 262,288), building upon previous observational studies. In the analysis, we mainly used the inverse-variance weighted (IVW) method of the random effects model, supplemented by the weighted median method and MR-Egger method.

SUBMITTER: Zhong S 

PROVIDER: S-EPMC10728005 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature