Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen Vu TH
PROVIDER: S-EPMC10728021 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Nguyen Vu Trang H TH Kikuchi Osamu O Ohashi Shinya S Saito Tomoki T Ida Tomomi T Nakai Yukie Y Cao Yang Y Yamamoto Yoshihiro Y Kondo Yuki Y Mitani Yosuke Y Kataoka Shigeki S Kondo Tomohiro T Katada Chikatoshi C Yamada Atsushi A Matsubara Junichi J Muto Manabu M
Cancer science 20230919 12
Despite advanced therapeutics, esophageal squamous cell carcinoma (ESCC) remains one of the deadliest cancers. Here, we propose a novel therapeutic strategy based on synthetic lethality combining trifluridine/tipiracil and MK1775 (WEE1 inhibitor) as a treatment for ESCC. This study demonstrates that trifluridine induces single-strand DNA damage in ESCC cells, as evidenced by phosphorylated replication protein 32. The DNA damage response includes cyclin-dependent kinase 1 (CDK1) (Tyr15) phosphory ...[more]