Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry.

ABSTRACT: Plasticity and homeostatic mechanisms allow neural networks to maintain proper function while responding to physiological challenges. Despite previous work investigating morphological and synaptic effects of brain-derived neurotrophic factor (BDNF), the most prevalent growth factor in the central nervous system, how exposure to BDNF manifests at the network level remains unknown. Here we report that BDNF treatment affects rodent hippocampal network dynamics during development and recovery from glutamate-induced excitotoxicity in culture. Importantly, these effects are not obvious when traditional activity metrics are used, so we delve more deeply into network organization, functional analyses, and in silico simulations. We demonstrate that BDNF partially restores homeostasis by promoting r

SUBMITTER: O'Neill KM 

PROVIDER: S-EPMC10728104 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature