β-Ketoallylic methylsulfones synthesis via inert C(sp³)-H bond activation by magnetic Ag-Cu MOF.

ABSTRACT: Herein, the one-pot tandem synthesis of β-ketoallylic methylsulfones has been achieved from readily available dimethyl sulfoxide and acetophenones as coupling partners in one step. In this procedure, dimethyl sulfoxide serves as a triple role including solvent, dual synthon and as an oxidant agent. The use of magnetic Ag-Cu MOF as a bimetallic catalyst is the key to the progress of the reaction due to its accessible active sites. It provides facile access to various β-ketoallylic methylsulfone derivatives from direct C(sp³)-H bond activation and functionalization of aromatic methyl ketones especially acetophenones with electron-rich and electron-poor groups. Moreover, the present work offers a synthetically powerful strategy to form products in good to excellent yields (74-96%)

SUBMITTER: Moghaddam FM 

PROVIDER: S-EPMC10728156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature