Accuracy and Precision of Iodine Quantification in Subtracted Micro-Computed Tomography: Effect of Reconstruction and Noise Removal Algorithms.

ABSTRACT:

Purpose

To evaluate the effect of reconstruction and noise removal algorithms on the accuracy and precision of iodine concentration (C_I) quantified with subtracted micro-computed tomography (micro-CT).

Procedures

Two reconstruction algorithms were evaluated: a filtered backprojection (FBP) algorithm and a simultaneous iterative reconstruction technique (SIRT) algorithm. A 3D bilateral filter (BF) was used for noise removal. A phantom study evaluated and compared the image quality, and the accuracy and precision of C_I in four scenarios: filtered FBP, filtered SIRT, non-filtered FBP, and non-filtered SIRT. In vivo experiments were performed in an animal model of chemically-induced mammary cancer.

Results

Linear relationships between the measured an

SUBMITTER: Ayala-Dominguez L 

PROVIDER: S-EPMC10728260 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature