Association of antihypertensive drugs with COVID-19 outcomes: a drug-target Mendelian randomization study.

ABSTRACT: Background: Observational investigations have provided conflicting results regarding the effect of antihypertensive drugs on the risk of COVID-19 outcomes. We intended to assess the causal effect of antihypertensive drugs on COVID-19 outcomes using drug-target Mendelian randomization (MR), mainly including angiotensin-converting enzyme inhibitors (ACEIs), β-blockers (BBs) and calcium channel blockers (CCBs). Methods: We used the genetic variants (minor allele frequency >1%, r ² < 0.30) located within 100 k bases of each drug target gene and associated with lower systolic blood pressure (p < 5 × 10^-8) as genetic proxies for antihypertensive drugs. COVID-19 outcomes included COVID-19 susceptibility (122,616 cases and 2,475,240 controls), hosp

SUBMITTER: Zhang K 

PROVIDER: S-EPMC10728283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature