Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery.

ABSTRACT:

Background

Multisystem inflammatory syndrome (MIS) in children is considered to be a post-infectious complication of COVID-19. T-cell responses in children with this condition have not been well-studied.

Methods

We aimed to study the immune responses in children with MIS in comparison to children with acute COVID-19 and children with other infections. Whole blood was stimulated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antigens and flow cytometry was performed to examine CD4⁺ and CD8⁺ T-cell responses.

Results

Children with MIS had higher frequencies of CD4⁺ and CD8⁺ T cells expressing cytokines at baseline and upon SARS-CoV-2 antigen-specific stimulation in comparison to children with COVID-

SUBMITTER: Pavan Kumar N 

PROVIDER: S-EPMC10728284 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature