Multi-animal-model study reveals mutations in neural plasticity and nociception genes linked to excessive alcohol drinking.

ABSTRACT:

Background

The basis for familial alcohol use disorder (AUD) remains an enigma due to various biological and societal confounds. The present study used three of the most adopted and documented rat models, combining the alcohol-preferring/non-alcohol-preferring (P/NP) lines and high alcohol-drinking/low alcohol-drinking (HAD/LAD) replicated lines, of AUD as examined through the lens of whole genomic analyses.

Methods

We used complete genome sequencing of the P/NP lines and previously published sequences of the HAD/LAD replicates to enhance the discovery of variants associated with AUD and to remove confounding with genetic background and random genetic drift. Specifically, we used high-order statistical methods to search for genetic variants whose frequency changes in whole s

SUBMITTER: Muir WM 

PROVIDER: S-EPMC10728351 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature