Alginate oligosaccharide extends the service lifespan by improving the sperm metabolome and gut microbiota in an aging Duroc boars model.

ABSTRACT:

Introduction

Alginate oligosaccharide (AOS), as a natural non-toxic plant extract, has been paid more attention in recent years due to its strong antioxidant, anti-inflammatory, and even anti-cancer properties. However, the mechanism by which AOS affects animal reproductive performance is still unclear.

Methods

The purpose of this study is to use multi-omics technology to analyze the effects of AOS in extending the service lifespan of aging boars.

Results

The results showed that AOS can significantly improve the sperm motility (p < 0.05) and sperm validity rate (p < 0.001) of aging boars and significantly reduce the abnormal sperm rate (p < 0.01) by increasing the protein levels such as CatSper 8 and protein kinase A (PKA) for semen quality. At th

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10728478 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature