Human neutrophil extracellular traps do not impair in vitro Toxoplasma gondii infection.

ABSTRACT:

Introduction

Toxoplasma gondii, responsible for causing toxoplasmosis, is a prevalent food and waterborne pathogen worldwide. It commonly infects warm-blooded animals and affects more than a third of the global human population. Once ingested, the parasite enters the host's small intestine and rapidly disseminates throughout the body via the bloodstream, infiltrating various tissues. Leukocyte-driven responses are vital against T. gondii, with neutrophils playing a dual role: swiftly recruited to infection sites, releasing inflammatory mediators, and serving as a replication hub and Trojan horses, aiding parasite spread. Neutrophils from various hosts release extracellular traps (NETs) against the protozoan. However, gaps persist regarding the mechanisms of NETs produ

SUBMITTER: Macedo IS 

PROVIDER: S-EPMC10728484 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature