Musclin prevents depression-like behavior in male mice by activating urocortin 2 signaling in the hypothalamus.

ABSTRACT:

Introduction

Physical activity is recommended as an alternative treatment for depression. Myokines, which are secreted from skeletal muscles during physical activity, play an important role in the skeletal muscle-brain axis. Musclin, a newly discovered myokine, exerts physical endurance, however, the effects of musclin on emotional behaviors, such as depression, have not been evaluated. This study aimed to access the anti-depressive effect of musclin and clarify the connection between depression-like behavior and hypothalamic neuropeptides in mice.

Methods

We measured the immobility time in the forced swim (FS) test, the time spent in open arm in the elevated-plus maze (EPM) test, the mRNA levels of hypothalamic neuropeptides, and enumerated the c-Fos-positive cells in the p

SUBMITTER: Ataka K 

PROVIDER: S-EPMC10728487 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature