Protective effect of miR-18a in resected liver metastases of colorectal cancer and FOLFOX treatment.

ABSTRACT:

Background

Colorectal cancer ranks second in terms of cancer associated deaths worldwide, whereas miRNA play a pivotal role in the etiology of cancer and its metastases.

Aims

Studying the expression and cellular function of miR-18a in metastatic colorectal cancer and association to progression-free survival.

Methods and results

Colorectal liver metastases (N = 123) and primary colorectal cancer (N = 27) where analyzed by RT-PCR and correlated with clinical follow up data. Invasion and migration assays were performed with the liver metastatic cell line LIM2099 after miR-18a knockdown. Cell viability under FOLFOX treatment and knockdown was measured. We found that the expression of miR-18a was increased 4.38-fold in liver metastases and 3.86-fold in colorectal tumor tis

SUBMITTER: Franz C 

PROVIDER: S-EPMC10728504 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature