Investigation of pathogenic germline variants in gastric cancer and development of "GasCanBase" database.

ABSTRACT:

Background

Gastric cancer, which is also known as stomach cancer, can be influenced by both germline and somatic mutations. Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) in germline have long been reported to play a pivotal role in cancer progression.

Aim

The aim of this study is to examine the nsSNP in GC-associated genes. The study also aims to develop a database with extensive information regarding the nsSNPs in the GC-associated genes and their impacts.

Methods and results

A total of 34,588 nsSNPs from 1,493,460 SNPs of the 40 genes were extracted from the available SNP database. Drug binding and energy minimization were examined by molecular docking and YASARA. To validate the existence of the germline CDH1 gene mutation (rs34466743) in the isolated blo

SUBMITTER: Hossain MU 

PROVIDER: S-EPMC10728505 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature