Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice.

ABSTRACT:

Background

Anaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the first-line treatment for anaphylaxis outside a perioperative reaction. Adrenaline autoinjectors (AAIs) are widely used self-administrable devices, especially in community settings. Different commercial AAIs have been authorized to be marketed in Europe. For an AAI to be efficacious, a rapid adrenaline delivery in patients, including those who are overweight or obese, resulting in an optimal cardiovascular (CV) response, is a key feature. AAIs are designed to achieve this requirement, which is reflected in their differing functional properties such as primary container selection, drug delivery mecha

SUBMITTER: Worm M 

PROVIDER: S-EPMC10728507 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature