ScANANSE gene regulatory network and motif analysis of single-cell clusters.

ABSTRACT: The recent development of single-cell techniques is essential to unravel complex biological systems. By measuring the transcriptome and the accessible genome on a single-cell level, cellular heterogeneity in a biological environment can be deciphered. Transcription factors act as key regulators activating and repressing downstream target genes, and together they constitute gene regulatory networks that govern cell morphology and identity. Dissecting these gene regulatory networks is crucial for understanding molecular mechanisms and disease, especially within highly complex biological systems. The gene regulatory network analysis software ANANSE and the motif enrichment software GimmeMotifs were both developed to analyse bulk datasets. We developed scANANSE, a software pipeline for gene re

SUBMITTER: Smits JGA 

PROVIDER: S-EPMC10728588 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature