Impact of disulfidptosis-associated clusters on breast cancer survival rates and guiding personalized treatment.

ABSTRACT:

Background

Breast cancer (BC) poses a serious threat to human health. Disulfidptosis is a recently discovered form of cell death associated with cancer prognosis and progression. However, the relationship between BC and disulfidptosis remains unclear.

Methods

We integrated single-cell sequencing and transcriptome sequencing in BC to assess the abundance and mutation status of disulfidptosis-associated genes (DAGs). Subsequently, we clustered the samples based on DAGs and constructed a prognostic model associated with disulfidptosis. Additionally, we performed pathway enrichment, immune response, and drug sensitivity analyses on the model. Finally, we validated the prognostic genes through Immunohistochemistry (IHC).

Results

The single-cell analysis identified 21 cell

SUBMITTER: Chen X 

PROVIDER: S-EPMC10728640 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature