SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway.

ABSTRACT:

Background

Serpin Family H Member 1 (SERPINH1) may be involved in the regulation of occurrence and development of tumors. However, the role and mechanism of SERPINH1 in osteosarcoma remain poorly understood. The aim of this study is to investigate the expression and role of SRPINH1 in osteosarcoma and to elucidate its underlying mechanisms.

Methods

First, we examined the expression of SERPINH1 in osteosarcoma and analyzed publicly available datasets to investigate whether SERPINH1 expression was associated with the prognosis of osteosarcoma. Then we constructed SERPINH1 overexpression and knockdown systems in osteosarcoma cells, and examined the proliferation, migration and invasion ability of osteosarcoma cells after SERPINH1 expression changes using CCK-8 assay, wound heal

SUBMITTER: Xia K 

PROVIDER: S-EPMC10728702 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature