Biological analysis of the potential pathogenic mechanisms of Infectious COVID-19 and Guillain-Barre syndrome.

ABSTRACT:

Background

Guillain-Barré syndrome (GBS) is a medical condition characterized by the immune system of the body attacking the peripheral nerves, including those in the spinal nerve roots, peripheral nerves, and cranial nerves. It can cause limb weakness, abnormal sensations, and facial nerve paralysis. Some studies have reported clinical cases associated with the severe coronavirus disease 2019 (COVID-19) and GBS, but how COVID-19 affects GBS is unclear.

Methods

We utilized bioinformatics techniques to explore the potential genetic connection between COVID-19 and GBS. Differential expression of genes (DEGs) related to COVID-19 and GBS was collected from the Gene Expression Omnibus (GEO) database. By taking the intersection, we obtained shared DEGs for COVID-19 and GBS. Subseq

SUBMITTER: Gao H 

PROVIDER: S-EPMC10728822 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature