Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses.

ABSTRACT:

Background

Inflammation is associated with cognitive functioning and dementia in older adults, but whether inflammation is related to cognitive functioning in youth and whether these associations are causal remains unclear.

Methods

In a population-based cohort (Avon Longitudinal Study of Parents and Children; ALSPAC), we investigated cross-sectional associations of inflammatory markers (C-reactive protein [CRP], Interleukin-6 [IL-6] and Glycoprotein acetyls [GlycA]) with measures of cold (working memory, response inhibition) and hot (emotion recognition) cognition at age 24 (N = 3,305 in multiple imputation models). Furthermore, we conducted one-sample and two-sample bidirectional Mendelian randomization (MR) analyses to examine potential causal effects of genetically-proxie

SUBMITTER: Slaney C 

PROVIDER: S-EPMC10728829 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature