Dataset Information

In Vitro and In Vivo Antidiabetic, α-Glucosidase Inhibition and Antibacterial Activities of Three Brown Algae, Polycladia myrica, Padina antillarum, and Sargassum boveanum, and a Red Alga, Palisada perforata from the Persian Gulf.

ABSTRACT:

Background

In recent decades, algae have attracted worldwide attention for their great biological activities, such as antidiabetic and antibacterial properties.

Objectives

We measured antibacterial and α-glucosidase inhibition potential of methanol and 80% methanol extracts of three brown algae species, Polycladia myrica, Padina antillarum, and Sargassum boveanum, and a red alga, Palisada perforata, from the Persian Gulf coasts.

Methods

Antibacterial activity of the algal extracts was assessed by broth dilution method against three gram-negative and -positive bacteria, including Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa; Staphylococcus epidermidis, Staphylococcus aureus, and Bacillus subtilis, respectively. Furthermore, the yeast's α-glucosidase inhibition of the algal extracts was measured via colorimetric assay. In addition, we investigated the beneficial effect of 80% MeOH extract of S. boveanum on the blood glucose levels in streptozotocin-induced diabetic rats.

Results

The MeOH extract of S. boveanum was the best antibacterial extract with MIC = 2.5 mg/mL against all bacterial strains except for E. coli. The MeOH and 80% MeOH extracts of P. myrica and P. antillarum inhibited α-glucosidase at most with IC₅₀ values of 12.70 ± 1.88 µg/mL and 13.06 ± 4.44 µg/mL, respectively. The oral gavage of S. boveanum extract in streptozotocin- (STZ-) induced diabetic rats resulted in decreasing their postprandial blood glucose levels. The algae and acarbose decreased blood glucose levels after sucrose administration in 60 minutes, compared to the non-drug-treated animals, with p values of 0.03 and 0.007, respectively.

Conclusions

Overall, due to the in vitro and in vivo antidiabetic potential of S. boveanum, we suggest the alga as a new source for the isolation and identification of potential antidiabetic and antibacterial compounds.

SUBMITTER: Moheimanian N

PROVIDER: S-EPMC10728852 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

In Vitro and In Vivo Antidiabetic, α-Glucosidase Inhibition and Antibacterial Activities of Three Brown Algae, <i>Polycladia myrica</i>, <i>Padina antillarum</i>, and <i>Sargassum boveanum</i>, and a Red Alga, <i>Palisada perforata</i> from the Persian Gulf.

Moheimanian Niloofar N Mirkhani Hossein H Purkhosrow Azar A Sohrabipour Jelveh J Jassbi Amir Reza AR

Iranian journal of pharmaceutical research : IJPR 20230101 1

<h4>Background</h4>In recent decades, algae have attracted worldwide attention for their great biological activities, such as antidiabetic and antibacterial properties.<h4>Objectives</h4>We measured antibacterial and α-glucosidase inhibition potential of methanol and 80% methanol extracts of three brown algae species, <i>Polycladia myrica</i>, <i>Padina antillarum</i>, and <i>Sargassum boveanum</i>, and a red alga, <i>Palisada perforata</i>, from the Persian Gulf coasts.<h4>Methods</h4>Antibacte ...[more]

PMID: 38116547

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