The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.

ABSTRACT:

Context

Several observational studies have found that hypothyroidism is associated with diabetes and its microvascular complications. However, the cause and effect have not been clarified.

Objective

The aim of the study was to examine the causality of such associations by a Mendelian randomization study.

Methods

Two-sample Mendelian randomization analysis was conducted to investigate the associations. Summary statistics for hypothyroidism were from the UK Biobank, and diabetes and its microvascular complications were from the largest available genome-wide association studies. MR-Egger, weighted median, inverse variance weighted, simple mode and weighted mode were used to examine the causal associations, and several sensitivity analyses were used to assess pleiotropy.<

SUBMITTER: Fang T 

PROVIDER: S-EPMC10728873 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature