Investigating trial design variability in trials of disease-modifying therapies in Parkinson's disease: a scoping review protocol.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a debilitating neurological disorder for which the identification of disease-modifying interventions represents a major unmet need. Diverse trial designs have attempted to mitigate challenges of population heterogeneity, efficacious symptomatic therapy and lack of outcome measures that are objective and sensitive to change in a disease modification setting. It is not clear whether consensus is emerging regarding trial design choices. Here, we report the protocol of a scoping review that will provide a contemporary update on trial design variability for disease-modifying interventions in PD.

Methods and analysis

The Population, Intervention, Comparator, Outcome and Study design (PICOS) framework will be used to structure the review, in

SUBMITTER: Zeissler ML 

PROVIDER: S-EPMC10729184 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature