Methodological and analytical considerations for intra-operative microdialysis.

ABSTRACT:

Background

Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of surgery, but have rarely been analyzed via interstitial fluid collected via microdialysis. To that end, we obtained an investigational device exemption for high molecular weight catheters (HMW, 100 kDa) and a variable flow rate pump to perform microdialysis at flow rates amenable to an intra-operative setting. We herein report on the lessons and insights obtained during our intra-operative HMW microdialysis trial, both in regard to methodological and analytical considerations.

Methods

Intra-operative HMW microdialysis was performed during 15

SUBMITTER: Riviere-Cazaux C 

PROVIDER: S-EPMC10729367 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature