Association between allostatic load and breast cancer risk: a cohort study.

ABSTRACT:

Background

Allostatic load (AL) reflects the collective load of chronic stress during lifetime. Previous studies have shown that higher AL is associated with poor clinical outcomes among breast cancer patients. However, the relationship between AL and breast cancer risk is still unclear.

Methods

To fill the gap, we analyzed the association between AL and the development of breast cancer in 181,455 women identified from the UK Biobank.

Results

During the follow-up from 2006 to 2020, 5,701 women were diagnosed with incident breast cancer. Significantly higher AL was observed among incident breast cancer cases than all study participants (mean: 2.77 vs. 2.63, P < 0.01). Univariate Cox regression analysis indicated the risk of breast cancer was increased by 5% per one AL

SUBMITTER: Guan Y 

PROVIDER: S-EPMC10729373 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature