HLA-based banking of induced pluripotent stem cells in Saudi Arabia.

ABSTRACT:

Background

Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the genetic engineering of hypo-immunogenic iPS cell lines is hampered with numerous hurdles. Therefore, it is increasingly interesting to create cell stocks based on HLA haplotype distribution in a given population. This study aimed to assess the potential of HLA-based iPS banking for the Saudi population.

Methods

In this study, we interrogated the HLA database of the Saudi Stem Cell Donor Registry (SSCDR), containing high-resolution HLA genotype data from 64,315 registered Saudi donors at the time of analysis. This database was considered to be a representative sample of the Saud

SUBMITTER: Alowaysi M 

PROVIDER: S-EPMC10729375 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature