Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus.

ABSTRACT: Social interactions affect physiological and pathological processes, yet their direct impact in peripheral tissues remains elusive. Recently we showed that disruption of pair bonds in monogamous Peromyscus californicus promotes lung tumorigenesis, pointing to a direct effect of bonding status in the periphery (Naderi et al., 2021). Here we show that lung transcriptomes of tumor-free Peromyscus are altered in a manner that depends on pair bonding and superseding the impact of genetic relevance between siblings. Pathways affected involve response to hypoxia and heart development. These effects are consistent with the profile of the serum proteome of bonded and bond-disrupted Peromyscus and were extended to lung cancer cells cultured in vitro, with sera from animals that differ in bonding exp

SUBMITTER: Naderi A 

PROVIDER: S-EPMC10729396 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature